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Introduction to MesoBlemish

Whether you use our serums as a professional for patient application, or as a consumer looking for holistic alternatives for natural skincare and health, our mesotherapy serums are advanced technology derived from active ingredients such as: plant stem cells, peptides, liposomes, algae, herbal extracts, minerals and vitamins - everything to provide safe, instant and long-lasting beauty effects without irritation. This is for both topical application as part as your daily skincare regimen or for deeper penetration which we turn to the microneedle to infuse the serums into the epidermis or dermis layer of skin. 

This mini course will focus on the application of the Scalpa MesoBlemish serum through the infusion of microneedling. MesoBlemish is a serum designed for oily and combination skin with a tendency to pimples, blackheads and whiteheads. Ideal soothing solution for irritated skin with acne problems and post-acne pigmentation. 

Benefits of MesoBlemish:

  • Reduces inflammation and itching 
  • Supports in reduction of bacterial colonization 
  • Helps to regulate sebum production
  • Minimizes the appearance of enlarged pores 
  • Restores skin balance 

About The MesoBlemish Serum

Recommended Use For:

  • Recommended for skin of all ages 
  • Unisex: for women and men, for skin of all types 
  • Hyperpigmentation (dark spots) 
  • Dry and dehydrated skin 
  • Sun-damaged skin 
  • Skin with roughness symptoms 
  • Skin itching symptoms 
  • Skin irritation from dehydration 
  • Grey skin color 
  • Lack of skin elasticity and firmness 
  • Post-acne scars (stimulates skin renewal) 

Active Ingredients:

Oleanolic Acid + NDGA Acid + Fleischer’s Willowherb + Oenothein A B + Phenolic Acids (Gallic + Ellagic) + Bioflavonoids (Quercitrin + Myricitrin) 

Full List of Ingredients:

Water/Aqua, Glycerin, Epilobium Fleischeri Extract, Nordihydroguaiaretic Acid, Oleanolic Acid, Butylene Glycol, Caprylyl Glycol, Biotin, Sodium Polyacrylate Starch, PEG-60 Almond Glycerides, PPG-5-Ceteth-20, Ethylhexylglycerin, Potassium Sorbate, Sodium Metabisulfite, Sodium Citrate, Citric Acid, Carbomer, Phenoxyethanol.


Fully safe. Trusted quality. 

Paraben Free | Fragrance Free | Alcohol Free | Colorants Free | Allergen Free | Methylisothiazolinone (MIT/MI) Free. Free of formaldehyde (FD) = does not contain DMDM Hydantoin, Diazolidinyl Urea, Imidazolidinyl Urea, Methenamine, Quaternium-15, and Sodium Hydroxymethylglycinate. 

How MesoLipo Can Be Used:

  • Mesotherapy 
  • Electroporation (electrophoresis) 
  • Ultrasounds (sonophoresis) 
  • (Serum does not contain ions, but it contains acids) 
  • Dermapen/ Microneedling
  • Oxygen therapy 
  • Post abrasion skincare 
  • Under algae peel-off beauty mask 
  • Under facial cream 
  • Daily skincare with topical use 

Application Area:

All skin areas with acne symptoms and dark spots caused by inflammatory states (face, neck, décolletage, shoulders, back). 

Cautions & Contraindications: 

  • For external use only. 
  • The product is not intended for use with single needle injections. 
  • Keep out of the reach of children. 
  • hypersensitivity to any component of the formulation.

Let's Discuss Acne

What Is Acne?

Acne starts when greasy secretions from the skin's sebaceous glands (oil glands) plug the tiny openings for hair follicles (clogged pores). If the openings are large, the clogs take the form of blackheads: small, flat spots with dark centers. If the openings stay small, the clogs take the form of whiteheads: small, flesh-colored bumps. Both types of clogged pores can develop into swollen, tender inflammations or pimples or deeper lumps or nodules. Nodules associated with severe cases of acne known as cystic acne, are firm swellings below the skin's surface that become inflamed, tender, and sometimes infected.

Although acne remains largely a curse of adolescence, about 20% of all cases occur in adults. Acne commonly starts during puberty between the ages of 10 and 13 and tends to be worse in people with oily skin. Teenage acne usually lasts for 5 to 10 years, normally going away during the early 20s. It occurs in both sexes, although teenage boys tend to have the most severe cases. Women are more likely than men to have mild to moderate forms into their 30s and beyond.

Acne lesions are most common on the face, but they can also occur on the neck, chest, back, shoulders, and upper arms. Heredity and hormones are behind most forms of acne.  

What Causes Acne? 

The cause of acne is not fully understood. Though stress can aggravate acne, it clearly does not cause it.Acne in teenagers starts with an increase in hormone production. During puberty, both boys and girls produce high levels of androgens, the male sex hormones that include testosterone. Testosterone signals the body to make more sebum, the oil produced in the skin's oil glands.

Excess sebum clogs the openings to hair follicles, especially those on the face, neck, chest, and back. Bacteria grows in these clogged follicles. This makes blackheads or whiteheads, also known as comedones which form on the skin's surface. Sometimes, this clogging causes the follicle wall to break under the pressure of this buildup. When this happens, sebum leaks into nearby tissues and forms a pustule or a papule; this is called inflammatory acne. The larger, tender pustules are called nodules.

Some oral contraceptives may trigger acne in some women but suppress it in others. Some injectable contraceptives and birth control devices may also cause acne. Steroids taken by some bodybuilders and other athletes can also lead to severe outbreaks.

People who escaped their teen years almost pimple-free may develop persistent adult-onset acne as they get older. Despite the normal increase in androgen levels during puberty, some doctors believe that flare-ups of acne have less to do with androgen levels than with how a person's skin responds to an increase in sebum production or to the bacteria that causes acne. Some people are simply more sensitive than others to this reaction. Sebum levels that might cause a pimple or two in one person may result in widespread outbreaks or even acute cystic acne in another person.


Effectiveness of Microneedling for Acne Scars:

Microneedling uses fine needles to prick your skin creating microscopic channels. As the practitioner pricks your skin, the skin then produces collagen in an effort to heal the microscopic channels (holes) we just created. The collagen that’s formed will help smooth out your skin’s appearance, helping to fill in fine lines, wrinkles, and scars. 

Microneedling works best for depressed, not raised, acne scars. If the acne scars are raised it typically is a sign that you already have excess collagen in that area.Another advantage of Microneedling is that it is considered safe for darker skin tones. This is because it doesn’t damage or remove the outer layer of skin. Microneedling is also considered safe for thin and sensitive skin as well. 

Side Effects of Microneedling for Acne Scars:

Some minor side effects can occur from this procedure. These include stinging, burning, redness, bruising, and inflammation. However, these should clear up within a few hours to a few days depending on your skin sensitivity. 

During the first few days after a microneedling procedure, you’ll want to advise your client to avoid direct sun exposure and rigorous exercise. Exfoliants and alcohol-based skin products can also make side effects worse. 

The skin may also respond to microneedling by acne breakouts after skin needling. However, these should be mild and clear up on their own.Advise your clients to avoid picking at the skin, as this can lead to further scarring and bacteria transfer from hands to face. 


Please share the following with your client:

It’s best to prepare for microneedling with Mesoblemish by doing the following: 

-Avoid tanning or direct sun exposure as it can irritate the skin, making inflammation worse. 

-Drinking plenty of water the day before and during the hours leading up to your treatment as water can reduce the chances of bruising and inflammation. 

-Come to your appointment without any makeup on. 

-Microneedling is not recommended for your acne scars if you’re currently experiencing an acne breakout or have open lesions. 

-It’s also not recommended if you have rosacea or eczema, as the procedure can worsen your symptoms. 

-If the client scars easily, microneedling is not recommended as it could potentially create more scars on top of the ones caused by acne. 

-Finally, a person shouldn’t get this treatment if they’re pregnant or have recently had skin radiation therapies.  


Mesotherapy Infusion Through Microneedling 

Benefits of MesoBlemish Infusion for Acne:

MesoBlemish has multiple benefits in treating acne. Firstly, the formation of micro-channels enables healing proteins, nutrients and vitamins to penetrate the skin and be absorbed. It also reduces inflammation and itching, supports in reduction of bacterial colonization, helps to regulate sebum production, minimizes the appearance of enlarged pores and restores skin balance. MesoBlemish can also be used as a topical serum every day, twice a day for added benefits, and infused twice or once a month for deep cleansing. 

Directions for Topical Application: 

On clean and toned skin, apply a few drops of meso serum into the palm of your hand, apply hand with serum to selected area on face or body and gently massage into skin. Follow with moisturizer or night cream. For best results repeat application process twice a day; morning and before bedtime.  

Mesotherapy Infusion Through Micro-Needling: 

Mesotherapy Infusion through micro-needling is a skin-enhancing treatment done using the Scalpa Surface Pen or derma pen paired with mesotherapy infusion serums. Micro-needling allows for the skin to be broken for the serums to enter at different depths. Micro-needle treatments use a pen-like device that oscillates a tip up and down to stimulate a skin reaction. This induces cell turnover, serum infusion and provoke the healing process that results in skin transformation and rejuvenation. Micro-needling alone offers many benefits for skin enhancement.

Benefits of Micro-Needling: 

• Cost-effectiveness (less expensive than other resurfacing procedures) 

• Improved effectiveness of topical agents used in conjunction with micro-needling 

• Pore size-reduction 

• Scar reduction including acne scars 

• Improved appearance of stretch marks 

• Wrinkle reduction 

• Fat Reduction 

• Collagen Production 

• Suitable for most skin types 

In the case of this training, we will be discussing application using micro-needling infusion of MesoBlemish.   

Using The Scalpa Surface Pen & Micro-Needle Cartridges: 

The Scalpa Surface Derma Pen offers depths from .25mm-3mm. We offer 12 and 36 needle cartridges to be used for this procedure. Knowing the different depths and cartridges is important in understanding which to use for your procedure.

Important Note On Needle Depths!  

The needle depth you, as a professional, can perform will be determined by your license, governing board, state, and country. In most US states, licensed cosmetologists and estheticians can penetrate up to .25. needle depth. Licensed tattoo artists, physicians and nurses can penetrate much deeper. What’s great about our Mesotherapy infusion serums is that they also work topically very well, and there are many methods and procedures available to help push these serums deeper into the dermis and subcutaneous layer of skin. Please research your laws and regulations per your area before performing this procedure as a profession. 

Directions For Micro-Needling Application:  

Either as a professional performing this procedure on your patient/client or as a consumer performing at home with a micro-needle pen, the directions are the same... 

If you plan to apply serum as you needle, it is important to set your needle depth no deeper than .25mm. Apply a few drops to the area and proceed to needle. Apply serum one section at a time and needle one section at a time until the serum has penetrated into the skin in that section. Never needle over dry skin as that can cause the needles to catch and tear the skin. Always keep it saturated with serum. Before moving onto the next section re-apply serum to the section you just completed. Continue to treat each section in the same manner, applying serums before and after needling. Complete three full passes over each section. Continue doing this until you have covered the entire area you are treating.

Directions For Deeper Depths:

If you plan to apply serum after you needle because you want to use a deeper needle setting for rejuvenation and needle benefits, please apply the numbing cream first to the area if you or your patient/client is sensitive to pain. Wrap with cellophane to expedite the numbing and wait 20-30 minutes for area to numb. Remove cellophane and proceed to microneedle at a needle depth of 2mm--3mm using plain water for slip. If blood is present wipe away before moving onto the next step. Once you have completed 2-3 passes over the area with needle pen, wait 5 minutes and then apply serum to area.

NOTE: Scalpa does sell a secondary numbing agent called Gone. This product is applied to broken skin to help keep area numb. Just a few drops will do a 4x4 area. This product would only be needed if patient is experiencing severe pain.

In the case of deeper needle depths, it is common for the serums to have a burning or warm sensation.Whichever method you decide to choose, we suggest using your pen's highest setting. This allows you to really penetrate the skin and create more micro-injuries.  

Directions for "Punch" Method: 

This is a technique used when you really want to inject the serum in a specific area. With your needle depth set to 1.5mm-3mm, you firmly press the cartridge against the skin and quickly lift directly up from skin. Proceed in this manner in the same area 3 to 4 times. It is not advisable to use this method for the entire face or area, but rather in the case of lips, age spots, acne areas, scars, inside stretch marks, inside and across deep lines and inside loose pockets of skin. Punch it three to four times and move to the next area. You do not need to revisit the same area. In the case of MesoBlemish, we could use this method on acne scars that we want to create more penetration. 

Combining Procedures and Equipment

Led Light Therapy (Blue)

Q: How does blue light technology Work?

A: Blue light therapy kills the acne-causing bacteria known as Propionibacterium acne, which can cause inflammation. Propionibacterium acne is sensitive to blue light. Blue light eliminates the bacteria found in the oil glands in the skin. The added presence of infrared light (heat) in the device causes the oil glands to shrink in size. The result is less oil in the skin and less bacteria, leading to the resolution of acne in the treated areas. 

Q: Why is it effective?

A: In most cases, it's all about bacteria formation inside our skin. Eliminating the bacteria from the skin with help from blue light decreases the inflammation associated with red pimples (papules) seen in acne. After a number of treatments, the blemishes disappear and skin regains its normal appearance. 

In the case of adding Blue Light Therapy to this procedure you would want to follow the meso infusion procedure with Led Light Therapy. For full benefits and instructions on the amazing world of LED Light Therapy, we strongly suggest you take the mini course titled Chromotherapy. 

Offering MesoLipo As A Service

Patient Consultation

It is suggested to perform a patient consultation prior to any treatment. This allows for you, the practitioner, to become aware of any possible reasons not to proceed with treatment, while also informing the patient a bit more about the treatment. Explain to your patient the treatment process. 

A Mesotherapy Infusion procedure is an application of active ingredient serums infused by micro-needling. For this procedure, you will be using MesoBlemish. 

The benefits of this procedure are not just to address problematic skin issues, but they will also experience cell turnover, collagen production and clearer skin. The serum itself is composed of natural ingredients that will benefit the skin in many ways. 

Depending on needle depth, you may want to consider numbing your patient. For MesoBlemish, we recommend a smaller needle depth so numbing may not be necessary. Bleeding and pain can occur, so please make your patient is aware of this and you are Blood Borne Pathogen certified if your area requires it, we will provide more information on this towards the end of the course.

For a series of treatments, three to six sessions two weeks apart is recommended for best results. 

Please make sure all intake forms are filled out including the health questionnaire so the best results possible can be obtained. If there are questions have them contact you prior to their appointment. It is encouraged to consider pre-booking sessions for better lasting results.  

Proper client intake forms will be provided for your use below.It is important that you keep fully detailed patient records for every single patient you have and session you perform. Patient/Client Record Cards/Consultation Forms should be completed on every visit a client makes to you.  

On their first visit, you will need to have a full consultation to ascertain if the patient has any problems or health issues. Following the consultation, when you have fully recorded the details, you need to ask your patient to sign the form to confirm that the details given are correct.   

Common Questions

Are there any risks?

The ingredients used in our mesotherapy serums are all natural and pose no risk The tiny pricking channels close within a few hours, and because the procedure is performed under clinical conditions, the likelihood of infection occurring is extremely low. 


What can I expect from Meso Infusion serums and procedure? 

The skin is cleaned and Scalpa Numb may be applied to lessen discomfort. The needle cartridge is selected based on the serum and area we will be treating. A small handheld pen-like device with a sterile, disposable tip with 12 or 36 tiny needles is then used to pierce the skin. Our needling pen’s multi-speed and adjustable needle depth allow needles to pierce the skin’s layer at 90 degrees and increase the absorption of products. 

How will I look after treatment? 

Most people will experience mild redness and possibly some swelling. The same way you may feel with a mild sunburn. Effects may last for 24-48 hours and there may be pinpoint bleeding and/or bruising. Within several days to several weeks you will notice a smoother, brighter, and more radiant appearance, however, the full effects of the treatment do not appear until several weeks to months later. 

What is the downtime like?

The inflammatory reaction of the skin is extremely short and fades significantly within hours from redness to pinkish which may last for 12 to 48 hours.

What effects does micro-needling have on the skin?

  • Improves the appearance of stretch marks 
  • Reduces pore size 
  • Improves the quality and texture of the skin 
  • Reduces fine lines and wrinkles 
  • Improves the look of disfiguring scars from surgery, accidents or acne. 

Will it be painful?

Scalpa Numb can be applied prior to the treatment which drastically minimizes or eliminates any pain altogether.  Scalpa Gone can also be applied once the skin has been broken.

How many treatments do I need and how often?

Micro-needling can be safely repeated every 4-6 weeks until you achieve the desired results. For collagen induction, we recommend starting with three treatments, but with a minimum separation time of 4 to 6 weeks between treatments. The number of treatments required will depend on how each individual responds to the treatments, our meso serums, and the extent of the damage at the beginning. Micro-needling can be used on all skin parts of the body. Most people will begin to see results after the very first appointment. 

How much does MesoBlemish Infusion treatment cost?

MesoBlemish Infusion with Micro-needling price will vary depending if we combine a second procedure. The procedure takes about 45-60 minutes and cost $99-$175 per session depending on the package designed for specifically for you. We also offer a discount on a package of 5 or more sessions.

Let's Talk Procedure!

Table Setup 

In this section, we will demonstrate the proper table set up and how to use additional products you will need for this treatment.

  • Table Towel 
  • Metal Tray 
  • Derma Pen 
  • Needle Cartridge 
  • MesoBlemish Serum 
  • Cotton Wipes 
  • Sharps Disposal Container 
  • Protective Technician Mask 
  • Technician Gloves 

Step By Step Instructions:

  1. Table Set-Up 
  2. Client Consultation
  3. Remove all traces of skincare products, use a cleanser on the area or baby wipes
  4.  Attach needle cartridge to microneedle pen (12 or 36 needle cartridge) 
  5.  Apply Meso Serum drops to the area you are working one section at a time or put in a container and use a silicone spatula depending on the method you will be using to apply serum. (see additional needle depth instructions above) 
  6. Continue to work the serum into the area for a total of (3) 5-10-minute application rounds 
  7. Rub meso serum in and make sure to cover every inch 
  8. Do not wash skin for 4-6 hours using only a mild soap 
  9. Proceed to next procedure if you are incorporating LED Light 

Let's Get Into The Procedure of MesoLipo Infusion Through Micro-Needle

Have your patient arrive wearing no skincare products on the area to be treated. If there are any skin lesions, please avoid treating the area and talk about rescheduling. 

Your prepping routine will differ depending if you apply serum during needling or after needling. 

  • You will always need to begin by cleansing the area. 
  • Next, depending on needle depth, you will want to leave Numb on the client for 15-30 minutes before proceeding. We suggest using Numb with a 1.5mm-3mm needle depth.
  •  Wipe the Numb off, if you’re using it. 
  • You can also opt to use another procedure prior to needling and Mesotherapy application such as microdermabrasion. 
  • For procedures using a 1.5mm-3mm needle depth, we suggest you needle first using water for slip (apply with cotton ball) then apply meso serums. 
  • For procedures using .25mm-1mm needle depth apply MesoBlemish as you needle. 
  • For MesoBlemish we suggest you use at least half or the entire 5ml vial per session. 
  • For easiest application, use MesoBlemish straight from the bottle using plastic drop applicator top. 

Live Procedural Videos

Health and Safety Guidelines

We at the Scalpa Training Academy encourage all students to take extra precaution when performing any procedure where blood borne pathogens may be present. 

In the United States, the government agency responsible for worker safety is the Occupational Safety and Health Administration otherwise known as OSHA. 

We also strongly suggest that all students complete the OSHA Blood Borne Pathogen Training Course to meet and satisfy the training requirement under the federal OSHA Blood Borne Pathogens Standard which prescribes safeguards to protect workers against the health hazards from exposure to blood and other potentially infectious materials and to reduce their risk from this exposure. Example health hazards include but are not limited to Hepatitis B, Hepatitis C, HIV, Malaria, Brucellosis, Syphilis, West Nile Virus, etc. 

Online training and certification are available through OSHA, and the training course is valid in all USA states.Here is the link to OSHA Blood Borne Pathogen Training Course… 


We at Scalpa, recommend that when working on any paying patron that you be fully insured for the procedures you are performing. Please check with your State for all important information pertaining to licensing and insurance. One company we recommend is Hands On Trade Association/PayneWest Insurance. 

They offer… 

•Liability Insurance for Independent Contractors 

•Professional & General Liability Insurance 

•Coverage travels with you anywhere you go to work 

•Multiple professions can be covered with only one policy 

Precautions and Protocols 

Any procedure where there is the possibility to blood exposure, you want to take every precaution available to you for both patient and practitioner safety.

Who Needs to Comply with OSHA Blood borne Pathogens?

Anyone who could be "reasonably anticipated" to face regular exposure to blood or OPIM (other potentially infectious materials) as a result of performing their job duties. 

This includes: 

Healthcare Workers 

Emergency Responders 

School and Day Care Staff 

Cleaning and Janitorial Staff 

Tattoo and Permanent Makeup Artists 

Cosmetologists & Aestheticians 

We at Scalpa Academy also encourage a professional interaction with patients and clients from the beginning to the end of their interaction with you as a practitioner. This includes but not limited to: 

Proper Consultation 

Intake Forms 

Client/Patient Files 

Procedure Table Set Up 

Patient/Client Follow Up 

At the end of this course we have provided the proper intake forms to use for your business. We begin with the Patient Health Disclosure Form. Because you are working with a procedure that may expose you and your patient/client to blood, it is important to gather their health information. 

Disclaimer of Medical and Legal Liability: Scalpa training courses are intended to provide the general knowledge to perform procedures but is not intended to be a substitute for medical advice, diagnosis or treatment. Reliance on the information in this training course for procedural purposes is to be used at your own risk. If you have questions or concerns, contact a medical professional prior to treatment. Scalpa is not held responsible or liable for risks involved with this procedure. 


Scalpa strongly advises each member or student to research their local legislation. It is your sole responsibility to check and clarify all rules and regulations pertaining to your country, state, city and county if you are planning on performing our training program procedures as a professional. Because Scalpa is offered worldwide, we cannot guarantee this information. Please check with your local health department, governing boards and FDA regulations regarding performance of any Scalpa course procedure. Scalpa is not held responsible or liable for legal encounters regarding licensing, regulations, or other legal aspects pertaining to procedural operation.